3WIX
Crystal structure of Mcl-1 in complex with compound 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 161 | 18204.7 | 4 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT |
| 2 | A, B, C, D | 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid | non-polymer | 466.5 | 4 | Chemie (LC3) | |||
| 3 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 172 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 167 | - | expression tag |
| Pro 168 | - | expression tag |
| Leu 169 | - | expression tag |
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72818.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1865.9 | |
| All* | Total formula weight | 74684.7 |
