3WII

Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific for the third fibronectin domain (Fn3) of human ROBO1.

Summary for 3WII

Entry DOI	10.2210/pdb3wii/pdb
Related	3WIH
Descriptor	anti-human ROBO1 antibody B2212A Fab light chain, anti-human ROBO1 antibody B2212A Fab heavy chain (3 entities in total)
Functional Keywords	immunoglobulin fab fragment, anti-hepatocellular carcinoma antibody, the third fibronectin type-iii domain (fn3) of human robo1, immune system
Biological source	Mus musculus More
Total number of polymer chains	4
Total formula weight	94749.04
Authors	Nakayama, T.,Mizohata, E.,Yamashita, T.,Nagatoishi, S.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Kado, Y.,Yokota, Y.,Sato, R.,Tsumoto, K.,Fujitani, H.,Kodama, T.,Hamakubo, T.,Inoue, T. (deposition date: 2013-09-12, release date: 2015-01-21, Last modification date: 2017-11-22)
Primary citation	Nakayama, T.,Mizohata, E.,Yamashita, T.,Nagatoishi, S.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Kado, Y.,Yokota, Y.,Satoh, R.,Tsumoto, K.,Fujitani, H.,Kodama, T.,Hamakubo, T.,Inoue, T. Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses Protein Sci., 24:328-340, 2015 Cited by PubMed: 25492858 DOI: 10.1002/pro.2619 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation