3WIG

Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP

3WIG の概要

• エントリーDOI: 10.2210/pdb3wig/pdb
• 関連するPDBエントリー: 3ORN 3OS3
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35612.89

構造登録者

Lukacs, C.M.,Janson, C.,Schuck, V. (登録日: 2013-09-12, 公開日: 2014-06-04, 最終更新日: 2024-03-20)

• 主引用文献: Lito, P.,Saborowski, A.,Yue, J.,Solomon, M.,Joseph, E.,Gadal, S.,Saborowski, M.,Kastenhuber, E.,Fellmann, C.,Ohara, K.,Morikami, K.,Miura, T.,Lukacs, C.,Ishii, N.,Lowe, S.,Rosen, N.; Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors; Cancer Cell, 25:697-710, 2014; PubMed: 24746704; DOI: 10.1016/j.ccr.2014.03.011

実験手法

X-RAY DIFFRACTION (2.7 Å)