3WHW

MTH1 in complex with Ruthenium-based inhibitor

Summary for 3WHW

• Entry DOI: 10.2210/pdb3whw/pdb
• Related: 3ZR1
• Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [4-amino-2-methyl-6-(pyridin-2-yl-kappaN)quinazolin-7-yl-kappaC~7~](carbonyl){1-[(2,6-dimethoxyphenoxy)carbonyl]cyclopenta-2,4-dien-1-yl}ruthenium, ... (4 entities in total)
• Functional Keywords: mth1, organometallic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639
• Total number of polymer chains: 2
• Total formula weight: 37834.55

Authors

Streib, M.,Kraeling, K.,Richter, K.,Steuber, H.,Meggers, E. (deposition date: 2013-09-03, release date: 2014-02-12, Last modification date: 2023-11-08)

• Primary citation: Streib, M.,Kraeling, K.,Richter, K.,Xie, X.,Steuber, H.,Meggers, E.; An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase.; Angew.Chem.Int.Ed.Engl., 53:305-309, 2014; PubMed: 24258965; DOI: 10.1002/anie.201307849

Experimental method

X-RAY DIFFRACTION (2.701 Å)