3WGW

Structure of PCNA bound to a small molecule inhibitor

3WGW の概要

• エントリーDOI: 10.2210/pdb3wgw/pdb
• 分子名称: Proliferating cell nuclear antigen, 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: dna binding, dna binding protein-inhibitor complex, dna binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59316.91

構造登録者

Hashimoto, H. (登録日: 2013-08-12, 公開日: 2014-02-05, 最終更新日: 2023-11-08)

• 主引用文献: Inoue, A.,Kikuchi, S.,Hishiki, A.,Shao, Y.,Heath, R.,Evison, B.J.,Actis, M.,Canman, C.E.,Hashimoto, H.,Fujii, N.; A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.; J.Biol.Chem., 289:7109-7120, 2014; PubMed: 24474685; DOI: 10.1074/jbc.M113.520429

実験手法

X-RAY DIFFRACTION (2.8 Å)