3WFG

Mineralocorticoid receptor ligand-binding domain with compuond 2e

Summary for 3WFG

Entry DOI	10.2210/pdb3wfg/pdb
Related	3VHU 3VHV 3WFF
Descriptor	Mineralocorticoid receptor, 6-[(2S)-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, transcription, hypertension, non-steroidal antagonist, activating mutation, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32810.85
Authors	Sogabe, S.,Habuka, N. (deposition date: 2013-07-19, release date: 2013-08-21, Last modification date: 2023-11-08)
Primary citation	Hasui, T.,Ohra, T.,Ohyabu, N.,Asano, K.,Matsui, H.,Mizukami, A.,Habuka, N.,Sogabe, S.,Endo, S.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S. Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists. Bioorg.Med.Chem., 21:5983-5994, 2013 Cited by PubMed: 23958516 DOI: 10.1016/j.bmc.2013.07.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation