3WFG
Mineralocorticoid receptor ligand-binding domain with compuond 2e
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE WFG A 1001 |
| Chain | Residue |
| A | LEU769 |
| A | CYS849 |
| A | MET852 |
| A | LEU938 |
| A | PHE941 |
| A | CYS942 |
| A | THR945 |
| A | VAL954 |
| A | PHE956 |
| A | HOH1115 |
| A | ASN770 |
| A | ALA773 |
| A | TRP806 |
| A | MET807 |
| A | SER811 |
| A | LEU814 |
| A | MET845 |
| A | LEU848 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1002 |
| Chain | Residue |
| A | TYR751 |
| A | ALA752 |
| A | ARG771 |
| A | LYS775 |
| A | ASP884 |
| A | HOH1153 |
| A | HOH1186 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1003 |
| Chain | Residue |
| A | GLN889 |
| A | SER949 |
| A | LYS953 |
| A | VAL954 |
| A | HOH1173 |
| A | HOH1289 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1004 |
| Chain | Residue |
| A | GLN803 |
| A | GLU962 |
| A | ILE963 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1005 |
| Chain | Residue |
| A | GLN889 |
| A | SER949 |
| A | HIS950 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1006 |
| Chain | Residue |
| A | GLN825 |
| A | PHE826 |
| A | ASN836 |
| A | GLU837 |
| A | MET840 |
| A | HIS853 |
| A | HOH1194 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1007 |
| Chain | Residue |
| A | ILE745 |
| A | TRP783 |
| A | HOH1141 |
| A | HOH1258 |
| A | HOH1266 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1008 |
| Chain | Residue |
| A | THR880 |
| A | HIS932 |
| A | VAL935 |
| A | HOH1152 |
| A | HOH1281 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1009 |
| Chain | Residue |
| A | ALA844 |
| A | MET845 |
| A | GLU847 |
| A | LEU848 |
| A | HOH1170 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1010 |
| Chain | Residue |
| A | THR865 |
| A | GLU868 |
| A | VAL907 |
| A | ASN913 |
| A | HOH1216 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1011 |
| Chain | Residue |
| A | TYR754 |
| A | ASP755 |
| A | LYS758 |
| A | PRO759 |
| A | ASP760 |
| A | ASN764 |
| A | LEU765 |
| A | THR768 |
| A | HOH1137 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1012 |
| Chain | Residue |
| A | GLN803 |
| A | ASP966 |
| A | LYS970 |
| A | HOH1131 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1013 |
| Chain | Residue |
| A | TYR899 |
| A | GLU902 |
| A | HOH1138 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1014 |
| Chain | Residue |
| A | THR800 |
| A | LYS970 |
| A | ASN975 |
| A | HOH1214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Region: {"description":"Important for coactivator binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15908963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
