3WFF
Mineralocorticoid receptor ligand-binding domain with compound 2b
Summary for 3WFF
Entry DOI | 10.2210/pdb3wff/pdb |
Related | 3VHU 3VHV 3WFG |
Descriptor | Mineralocorticoid receptor, 6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, transcription, hypertension, non-steroidal antagonist, activating mutation, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32102.90 |
Authors | Sogabe, S.,Habuka, N. (deposition date: 2013-07-19, release date: 2013-08-21, Last modification date: 2023-11-08) |
Primary citation | Hasui, T.,Ohra, T.,Ohyabu, N.,Asano, K.,Matsui, H.,Mizukami, A.,Habuka, N.,Sogabe, S.,Endo, S.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S. Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists. Bioorg.Med.Chem., 21:5983-5994, 2013 Cited by PubMed: 23958516DOI: 10.1016/j.bmc.2013.07.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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