3WE8
Pim-1 kinase in complex with Ruthenium-based inhibitor
Summary for 3WE8
| Entry DOI | 10.2210/pdb3we8/pdb |
| Related | 4AS0 |
| Descriptor | Serine/threonine-protein kinase pim-1, (carbonyl-kappaC)[(1,2,3,4,5-eta)-cyclopentadienyl](7-oxo-7,8-dihydro-1,8-phenanthrolin-10-yl-kappa~2~C~10~,N~1~)ruthenium(1+), SULFATE ION, ... (4 entities in total) |
| Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
| Total number of polymer chains | 1 |
| Total formula weight | 31903.09 |
| Authors | Waehler, K.,Kraeling, K.,Steuber, H.,Meggers, E. (deposition date: 2013-07-02, release date: 2014-05-21, Last modification date: 2026-08-12) |
| Primary citation | Wahler, K.,Kraling, K.,Steuber, H.,Meggers, E. Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor ChemistryOpen, 2:180-185, 2013 Cited by PubMed: 24551564DOI: 10.1002/open.201300031 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.954 Å) |
Structure validation
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