3WE8
Pim-1 kinase in complex with Ruthenium-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase pim-1 | polymer | 273 | 31417.7 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (A) | (carbonyl-kappaC)[(1,2,3,4,5-eta)-cyclopentadienyl](7-oxo-7,8-dihydro-1,8-phenanthrolin-10-yl-kappa~2~C~10~,N~1~)ruthenium(1+) | non-polymer | 389.4 | 1 | Chemie (RUI) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 285 | Chemie (HOH) |
Sequence modifications
A: 33 - 305 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | Arg 341 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31417.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 485.4 | |
| All* | Total formula weight | 31903.1 |
