3WD9

Crystal structure of phosphodiesterase 4B in complex with compound 10f

Summary for 3WD9

Entry DOI	10.2210/pdb3wd9/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 4-[(4-{2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}phenyl)amino]-2-phenylpyrimidine-5-carboxamide, ZINC ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, copd, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	87751.29
Authors	Takahashi, M.,Hanzawa, H. (deposition date: 2013-06-11, release date: 2013-10-23, Last modification date: 2023-11-08)
Primary citation	Goto, T.,Shiina, A.,Yoshino, T.,Mizukami, K.,Hirahara, K.,Suzuki, O.,Sogawa, Y.,Takahashi, T.,Mikkaichi, T.,Nakao, N.,Takahashi, M.,Hasegawa, M.,Sasaki, S. Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors Bioorg.Med.Chem., 21:7025-7037, 2013 Cited by PubMed: 24094436 DOI: 10.1016/j.bmc.2013.09.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation