3W6G

Structure of peroxiredoxin from anaerobic hyperthermophilic archaeon Pyrococcus horikoshii

3W6G の概要

• エントリーDOI: 10.2210/pdb3w6g/pdb
• 分子名称: Probable peroxiredoxin, CITRATE ANION (3 entities in total)
• 機能のキーワード: reduction, hydrogen peroxide, water, oxidoreductase
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 499595.90

構造登録者

Nakamura, T.,Mori, A.,Niiyama, M.,Matsumura, H.,Tokuyama, C.,Morita, J.,Uegaki, K.,Inoue, T. (登録日: 2013-02-14, 公開日: 2013-07-10, 最終更新日: 2024-03-20)

主引用文献

Nakamura, T.,Mori, A.,Niiyama, M.,Matsumura, H.,Tokuyama, C.,Morita, J.,Uegaki, K.,Inoue, T.
Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii
Acta Crystallogr.,Sect.F, 69:719-722, 2013

PubMed Abstract: The crystal structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii (PhPrx) was determined at a resolution of 2.25 Å. The overall structure was a ring-type decamer consisting of five homodimers. Citrate, which was included in the crystallization conditions, was bound to the peroxidatic cysteine of the active site, with two O atoms of the carboxyl group mimicking those of the substrate hydrogen peroxide. PhPrx lacked the C-terminal tail that forms a 32-residue extension of the protein in the homologous peroxiredoxin from Aeropyrum pernix (ApPrx).

PubMed: 23832195
DOI: 10.1107/S1744309113014036

実験手法

X-RAY DIFFRACTION (2.25 Å)