3W69
Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor
Summary for 3W69
Entry DOI | 10.2210/pdb3w69/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (5R,6S)-2-[((2S,5R)-2-{[(3R)-4-acetyl-3-methylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ubiquitin-protein ligase e3 mdm2, p53, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 2 |
Total formula weight | 22091.59 |
Authors | Shimizu, H.,Katakura, S.,Miyazaki, M.,Naito, H.,Sugimoto, Y.,Kawato, H.,Okayama, T.,Soga, T. (deposition date: 2013-02-12, release date: 2013-06-05, Last modification date: 2023-11-08) |
Primary citation | Miyazaki, M.,Naito, H.,Sugimoto, Y.,Yoshida, K.,Kawato, H.,Okayama, T.,Shimizu, H.,Miyazaki, M.,Kitagawa, M.,Seki, T.,Fukutake, S.,Shiose, Y.,Aonuma, M.,Soga, T. Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors Bioorg.Med.Chem., 21:4319-4331, 2013 Cited by PubMed: 23685175DOI: 10.1016/j.bmc.2013.04.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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