3W5E

Crystal structure of phosphodiesterase 4B in complex with compound 31e

Summary for 3W5E

• Entry DOI: 10.2210/pdb3w5e/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, copd, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 87845.45

Authors

Takahashi, M.,Hanzawa, H. (deposition date: 2013-01-28, release date: 2013-05-29, Last modification date: 2023-11-08)

• Primary citation: Goto, T.,Shiina, A.,Yoshino, T.,Mizukami, K.,Hirahara, K.,Suzuki, O.,Sogawa, Y.,Takahashi, T.,Mikkaichi, T.,Nakao, N.,Takahashi, M.,Hasegawa, M.,Sasaki, S.; Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors; Bioorg.Med.Chem.Lett., 23:3325-3328, 2013; PubMed: 23602400; DOI: 10.1016/j.bmcl.2013.03.104

Experimental method

X-RAY DIFFRACTION (2.3 Å)