3W3L

Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 1

3W3L の概要

• エントリーDOI: 10.2210/pdb3w3l/pdb
• 関連するPDBエントリー: 3W3G 3W3J 3W3K 3W3M 3W3N
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: leucine rich repeat, rna, glycosylation, rna recognition, ssrna, receptor, rna receptor, innate immunity, rna binding, secreted, resiquimod, antivirus and antitumor drug, antivirus and antitumor drug binding, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 386318.37

構造登録者

Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2012-12-22, 公開日: 2013-04-03, 最終更新日: 2020-07-29)

• 主引用文献: Tanji, H.,Ohto, U.,Shibata, T.,Miyake, K.,Shimizu, T.; Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands; Science, 339:1426-1429, 2013; PubMed: 23520111; DOI: 10.1126/science.1229159

実験手法

X-RAY DIFFRACTION (2.33 Å)