3W39

Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI)

3W39 の概要

• エントリーDOI: 10.2210/pdb3w39/pdb
• 分子名称: HLA class I histocompatibility antigen, B-52 alpha chain, Beta-2-microglobulin, peptid from Gag-Pol polyprotein (3 entities in total)
• 機能のキーワード: class i major histocompatibility complex, mhc, membrane, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P30490; Secreted: P61769; Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89731.51

構造登録者

Yagita, Y.,Kuse, N.,Kuroki, K.,Gatanaga, H.,Carlson, J.M.,Chikata, T.,Brumme, Z.L.,Murakoshi, H.,Akahoshi, T.,Pfeifer, N.,Mallal, S.,John, M.,Ose, T.,Matsubara, H.,Kanda, R.,Fukunaga, Y.,Honda, K.,Kawashima, Y.,Ariumi, Y.,Oka, S.,Maenaka, K.,Takiguchi, M. (登録日: 2012-12-13, 公開日: 2013-02-13, 最終更新日: 2023-11-08)

• 主引用文献: Yagita, Y.,Kuse, N.,Kuroki, K.,Gatanaga, H.,Carlson, J.M.,Chikata, T.,Brumme, Z.L.,Murakoshi, H.,Akahoshi, T.,Pfeifer, N.,Mallal, S.,John, M.,Ose, T.,Matsubara, H.,Kanda, R.,Fukunaga, Y.,Honda, K.,Kawashima, Y.,Ariumi, Y.,Oka, S.,Maenaka, K.,Takiguchi, M.; Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity; J.Virol., 87:2253-2263, 2013; PubMed: 23236061; DOI: 10.1128/JVI.02572-12

実験手法

X-RAY DIFFRACTION (3.1 Å)