3W0S

Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B

Summary for 3W0S

Entry DOI	10.2210/pdb3w0s/pdb
Related	3W0M 3W0N 3W0O 3W0P 3W0Q 3W0R
Descriptor	Hygromycin-B 4-O-kinase, HYGROMYCIN B VARIANT, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	phosphotransferase, transferase-antibiotic complex, transferase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	40224.06
Authors	Iino, D.,Takakura, Y.,Fukano, K.,Sasaki, Y.,Hoshino, T.,Ohsawa, K.,Nakamura, A.,Yajima, S. (deposition date: 2012-11-02, release date: 2013-08-07, Last modification date: 2024-03-20)
Primary citation	Iino, D.,Takakura, Y.,Fukano, K.,Sasaki, Y.,Hoshino, T.,Ohsawa, K.,Nakamura, A.,Yajima, S. Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant. J.Struct.Biol., 183:76-85, 2013 Cited by PubMed: 23747390 DOI: 10.1016/j.jsb.2013.05.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation