3VZV

Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor

Summary for 3VZV

Entry DOI	10.2210/pdb3vzv/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, 1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-(propan-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N-dimethyl-L-prolinamide (2 entities in total)
Functional Keywords	ubiquitin-protein ligase e3 mdm2, p53, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	2
Total formula weight	21553.07
Authors	Shimizu, H.,Katakura, S.,Miyazaki, M.,Naito, H.,Sugimoto, Y.,Kawato, H.,Okayama, T.,Soga, T. (deposition date: 2012-10-16, release date: 2013-02-06, Last modification date: 2024-03-20)
Primary citation	Miyazaki, M.,Naito, H.,Sugimoto, Y.,Kawato, H.,Okayama, T.,Shimizu, H.,Miyazaki, M.,Kitagawa, M.,Seki, T.,Fukutake, S.,Aonuma, M.,Soga, T. Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold Bioorg.Med.Chem.Lett., 23:728-732, 2013 Cited by PubMed: 23266121 DOI: 10.1016/j.bmcl.2012.11.091 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation