3VZC

Crystal structure of Sphingosine Kinase 1 with inhibitor

Summary for 3VZC

Entry DOI	10.2210/pdb3vzc/pdb
Related	3VZB 3VZD
Descriptor	Sphingosine kinase 1, 4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}phenol, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	lipid kinase, transferase-inhibitor complex, transferase/inhibitor
Biological source	homo sapiens
Cellular location	Cytoplasm: Q9NYA1
Total number of polymer chains	6
Total formula weight	241445.62
Authors	Min, X.,Walker, N.P.,Wang, Z. (deposition date: 2012-10-11, release date: 2013-05-08, Last modification date: 2024-03-20)
Primary citation	Wang, Z.,Min, X.,Xiao, S.H.,Johnstone, S.,Romanow, W.,Meininger, D.,Xu, H.,Liu, J.,Dai, J.,An, S.,Thibault, S.,Walker, N. Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. Structure, 21:798-809, 2013 Cited by PubMed: 23602659 DOI: 10.1016/j.str.2013.02.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation