3VW8

Crystal structure of human c-Met kinase domain with its inhibitor

3VW8 の概要

• エントリーDOI: 10.2210/pdb3vw8/pdb
• 分子名称: Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37593.85

構造登録者

Matsumoto, S.,Miyamoto, N.,Hirayama, T.,Oki, H.,Okada, K.,Tawada, M.,Iwata, H.,Miki, H.,Nakamura, K.,Hori, A.,Imamura, S. (登録日: 2012-08-08, 公開日: 2013-08-14, 最終更新日: 2024-05-29)

• 主引用文献: Matsumoto, S.,Miyamoto, N.,Hirayama, T.,Oki, H.,Okada, K.,Tawada, M.,Iwata, H.,Nakamura, K.,Yamasaki, S.,Miki, H.,Hori, A.,Imamura, S.; Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors.; Bioorg.Med.Chem., 21:7686-7698, 2013; PubMed: 24216091; DOI: 10.1016/j.bmc.2013.10.028

実験手法

X-RAY DIFFRACTION (2.1 Å)