3VW7

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

3VW7 の概要

• エントリーDOI: 10.2210/pdb3vw7/pdb
• 分子名称: Proteinase-activated receptor 1, Lysozyme, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]fur an-6-yl]carbamate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• 機能のキーワード: high resolution structure, protease-activated receptor 1, inactive conformation, antagonist vorapaxar, g protein-coupled receptor, signaling protein, membrane protein, thrombin receptor-antagonist complex, signaling protein-antagonist complex, signaling protein/antagonist
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P25116
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58098.87

構造登録者

Zhang, C.,Srinivasan, Y.,Arlow, D.H.,Fung, J.J.,Palmer, D.,Zheng, Y.,Green, H.F.,Pandey, A.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Coughlin, S.R.,Kobilka, B.K. (登録日: 2012-08-07, 公開日: 2012-12-12, 最終更新日: 2023-11-08)

• 主引用文献: Zhang, C.,Srinivasan, Y.,Arlow, D.H.,Fung, J.J.,Palmer, D.,Zheng, Y.,Green, H.F.,Pandey, A.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Coughlin, S.R.,Kobilka, B.K.; High-resolution crystal structure of human protease-activated receptor 1; Nature, 492:387-392, 2012; PubMed: 23222541; DOI: 10.1038/nature11701

実験手法

X-RAY DIFFRACTION (2.2 Å)