3VRB

Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil and substrate fumarate

3VRB の概要

• エントリーDOI: 10.2210/pdb3vrb/pdb
• 関連するPDBエントリー: 3VR8
• 分子名称: Flavoprotein subunit of complex II, PROTOPORPHYRIN IX CONTAINING FE, N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide, ... (12 entities in total)
• 機能のキーワード: ascaris suum, membrane protein, reductase, mitochondrial membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Ascaris suum (Pig roundworm); 詳細
• 細胞内の位置: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : Q33862 O44074; Mitochondrion inner membrane ; Multi-pass membrane protein : P92507
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 289071.41

構造登録者

Shimizu, H.,Shiba, T.,Inaoka, D.K.,Osanai, A.,Kita, K.,Sakamoto, K.,Harada, S. (登録日: 2012-04-07, 公開日: 2012-07-11, 最終更新日: 2024-11-06)

主引用文献

Shimizu, H.,Osanai, A.,Sakamoto, K.,Inaoka, D.K.,Shiba, T.,Harada, S.,Kita, K.
Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum
J.Biochem., 151:589-592, 2012

PubMed Abstract: In the anaerobic respiratory chain of the parasitic nematode Ascaris suum, complex II couples the reduction of fumarate to the oxidation of rhodoquinol, a reverse reaction catalyzed by mammalian complex II. In this study, the first structure of anaerobic complex II of mitochondria was determined. The structure, composed of four subunits and five co-factors, is similar to that of aerobic complex II, except for an extra peptide found in the smallest anchor subunit of the A. suum enzyme. We discuss herein the structure-function relationship of the enzyme and the critical role of the low redox potential of rhodoquinol in the fumarate reduction of A. suum complex II.

PubMed: 22577165
DOI: 10.1093/jb/mvs051

実験手法

X-RAY DIFFRACTION (2.91 Å)