3VQS

Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor

3VQS の概要

• エントリーDOI: 10.2210/pdb3vqs/pdb
• 関連するPDBエントリー: 1QUV 2DXS
• 分子名称: RNA-directed RNA polymerase, (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: rna-dependent rna polymerase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Hepatitis C virus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 259879.85

構造登録者

Adachi, T.,Doi, S.,Ando, I.,Sugimoto, K.,Orita, T.,Nomura, A.,Kamada, M. (登録日: 2012-03-30, 公開日: 2012-08-08)

• 主引用文献: Ando, I.,Adachi, T.,Ogura, N.,Toyonaga, Y.,Sugimoto, K.,Abe, H.,Kamada, M.,Noguchi, T.; Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase.; Antimicrob.Agents Chemother., 56:4250-4256, 2012; PubMed: 22615294; DOI: 10.1128/AAC.00312-12

実験手法

X-RAY DIFFRACTION (1.9 Å)