3VQH

Bromine SAD partially resolves multiple binding modes for PKA inhibitor H-89

3VQH の概要

• エントリーDOI: 10.2210/pdb3vqh/pdb
• 関連するPDBエントリー: 1YDT
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm. Isoform 2: Cell projection, cilium, flagellum: P17612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43679.49

構造登録者

Pflug, A.,Johnson, K.A.,Engh, R.A. (登録日: 2012-03-23, 公開日: 2012-08-15, 最終更新日: 2023-11-08)

• 主引用文献: Pflug, A.,Johnson, K.A.,Engh, R.A.; Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89; Acta Crystallogr.,Sect.F, 68:873-877, 2012; PubMed: 22869112; DOI: 10.1107/S1744309112028655

実験手法

X-RAY DIFFRACTION (1.95 Å)