3VMT
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog
Summary for 3VMT
Entry DOI | 10.2210/pdb3vmt/pdb |
Related | 3VMQ 3VMR 3VMS |
Descriptor | Monofunctional glycosyltransferase, [(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethylamino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]oxy-3-acetamido-5-[(2S,3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxan-2-yl] [oxidanyl(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl] hydrogen phosphate, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | transmembrane, glycosyltransferase, bacterial cell wall synthesis, membrane, transferase |
Biological source | Staphylococcus aureus |
Cellular location | Cell membrane; Single-pass membrane protein (By similarity): Q99T05 |
Total number of polymer chains | 2 |
Total formula weight | 62510.62 |
Authors | Huang, C.Y.,Shih, H.W.,Lin, L.Y.,Tien, Y.W.,Cheng, T.J.R.,Cheng, W.C.,Wong, C.H.,Ma, C. (deposition date: 2011-12-15, release date: 2012-04-18, Last modification date: 2023-11-08) |
Primary citation | Huang, C.Y.,Shih, H.W.,Lin, L.Y.,Tien, Y.W.,Cheng, T.J.R.,Cheng, W.C.,Wong, C.H.,Ma, C. Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism Proc.Natl.Acad.Sci.USA, 109:6496-6501, 2012 Cited by PubMed: 22493270DOI: 10.1073/pnas.1203900109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.299 Å) |
Structure validation
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