3VJH

Human PPAR GAMMA ligand binding domain in complex with JKPL35

Summary for 3VJH

• Entry DOI: 10.2210/pdb3vjh/pdb
• Related: 3VJI
• Descriptor: Peroxisome proliferator-activated receptor gamma, (2S)-2-[4-methoxy-3-({[4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]pentanoic acid (3 entities in total)
• Functional Keywords: transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 65484.73

Authors

Tomioka, D.,Kuwabara, N.,Hashimoto, H.,Sato, M.,Shimizu, T. (deposition date: 2011-10-20, release date: 2012-08-29, Last modification date: 2023-11-08)

Primary citation

Kuwabara, N.,Oyama, T.,Tomioka, D.,Ohashi, M.,Yanagisawa, J.,Shimizu, T.,Miyachi, H.
Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J.Med.Chem., 55:893-902, 2012

PubMed Abstract: Human peroxisome proliferator-activated receptors (hPPARs) are ligand-dependent transcription factors that control various biological responses, and there are three subtypes: hPPARα, hPPARδ, and hPPARγ. We report here that α-substituted phenylpropanoic acid-type hPPAR agonists with similar structure bind to the hPPAR ligand binding domain (LBD) in different conformations, depending on the receptor subtype. These results might indicate that hPPAR ligand binding pockets have multiple binding points that can be utilized to accommodate structurally flexible hPPAR ligands.

PubMed: 22185225
DOI: 10.1021/jm2014293

Experimental method

X-RAY DIFFRACTION (2.22 Å)