Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3VI8

Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13

Summary for 3VI8
Entry DOI10.2210/pdb3vi8/pdb
Related2znn
DescriptorPeroxisome proliferator-activated receptor alpha, (2S)-2-(4-methoxy-3-{[(pyren-1-ylcarbonyl)amino]methyl}benzyl)butanoic acid (3 entities in total)
Functional Keywordsnuclear receptor, protein-ligand complex, ppar, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q07869
Total number of polymer chains1
Total formula weight31321.59
Authors
Oyama, T.,Miyachi, H.,Morikawa, K. (deposition date: 2011-09-25, release date: 2012-08-29, Last modification date: 2023-11-08)
Primary citationKuwabara, N.,Oyama, T.,Tomioka, D.,Ohashi, M.,Yanagisawa, J.,Shimizu, T.,Miyachi, H.
Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype
J.Med.Chem., 55:893-902, 2012
Cited by
PubMed: 22185225
DOI: 10.1021/jm2014293
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon