3VHV

Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist

3VHV の概要

• エントリーDOI: 10.2210/pdb3vhv/pdb
• 関連するPDBエントリー: 3VHU
• 分子名称: Mineralocorticoid receptor, 6-[(7S)-7-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-2H-1,4-benzoxazin-3(4H)-one, 6-[(1E)-2-phenyl-N-(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]-2H-1,4-benzoxazin-3(4H)-one, ... (6 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, activating mutation, hypertension, non-steroidal antagonist, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P08235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31051.99

構造登録者

Sogabe, S.,Habuka, N. (登録日: 2011-09-07, 公開日: 2011-12-28, 最終更新日: 2023-11-08)

• 主引用文献: Hasui, T.,Matsunaga, N.,Ora, T.,Ohyabu, N.,Nishigaki, N.,Imura, Y.,Igata, Y.,Matsui, H.,Motoyaji, T.,Tanaka, T.,Habuka, N.,Sogabe, S.,Ono, M.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S.; Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists; J.Med.Chem., 54:8616-8631, 2011; PubMed: 22074142; DOI: 10.1021/jm2011645

実験手法

X-RAY DIFFRACTION (1.35 Å)