3VF5

Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031

Summary for 3VF5

Entry DOI	10.2210/pdb3vf5/pdb
Related	3H5B 3VF7 3VFA 3VFB
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	protease inhibitor, p1'-ligand, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	2
Total formula weight	22452.98
Authors	Yu, X.X.,Wang, Y.F.,Chang, Y.C.E.,Weber, I.T. (deposition date: 2012-01-09, release date: 2012-11-21, Last modification date: 2023-09-13)
Primary citation	Chang, Y.C.,Yu, X.,Zhang, Y.,Tie, Y.,Wang, Y.F.,Yashchuk, S.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring. J.Med.Chem., 55:3387-3397, 2012 Cited by PubMed: 22401672 DOI: 10.1021/jm300072d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation