3VET

Crystal structure of the O-carbamoyltransferase TobZ in complex with Tobramycin, carbamoyl phosphate and ADP

Summary for 3VET

Entry DOI	10.2210/pdb3vet/pdb
Related	3VEN 3VEO 3VER 3VES 3VEW 3VEX 3VEZ 3VF2 3VF4
Descriptor	O-carbamoyltransferase TobZ, ADENOSINE-5'-DIPHOSPHATE, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ... (9 entities in total)
Functional Keywords	antibiotic biosynthesis, substrate assisted catalysis, substrate channeling, adenylation, structural enzymology, enzyme evolution, transferase-antibiotic complex, transferase/antibiotic
Biological source	Streptoalloteichus tenebrarius (Streptomyces tenebrarius)
Total number of polymer chains	1
Total formula weight	65092.03
Authors	Parthier, C.,Stubbs, M.T.,Goerlich, S.,Jaenecke, F. (deposition date: 2012-01-09, release date: 2012-01-25, Last modification date: 2023-09-13)
Primary citation	Parthier, C.,Gorlich, S.,Jaenecke, F.,Breithaupt, C.,Brauer, U.,Fandrich, U.,Clausnitzer, D.,Wehmeier, U.F.,Bottcher, C.,Scheel, D.,Stubbs, M.T. The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction. Angew.Chem.Int.Ed.Engl., 51:4046-4052, 2012 Cited by PubMed: 22383337 DOI: 10.1002/anie.201108896 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation