3VET

Crystal structure of the O-carbamoyltransferase TobZ in complex with Tobramycin, carbamoyl phosphate and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0005506	molecular_function	iron ion binding
A	0005524	molecular_function	ATP binding
A	0009058	biological_process	biosynthetic process
A	0016138	biological_process	glycoside biosynthetic process
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0016874	molecular_function	ligase activity
A	0017000	biological_process	antibiotic biosynthetic process
A	0046872	molecular_function	metal ion binding
A	1901121	biological_process	tobramycin biosynthetic process
A	1901133	biological_process	kanamycin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP A 601

Chain	Residue
A	GLY186
A	ARG498
A	SER530
A	ASN532
A	ARG534
A	GLY535
A	CP602
A	MN605
A	HOH727
A	HOH827
A	HOH829
A	GLY190
A	HOH838
A	HOH988
A	ARG418
A	LYS443
A	ARG445
A	ARG449
A	PRO450
A	HIS492
A	SER496

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CP A 602

Chain	Residue
A	ARG418
A	ALA419
A	LYS443
A	MET473
A	ARG498
A	ASN528
A	THR529
A	SER530
A	ADP601
A	MN605
A	HOH803
A	HOH816
A	HOH988

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 603

Chain	Residue
A	HIS14
A	TRP71
A	HIS114
A	HIS118
A	ASP137
A	GLY138
A	GLN139
A	GLY168
A	TYR171
A	GLU172
A	PRO185
A	GLY310
A	VAL311
A	LEU313
A	ASN314
A	SER337
A	ASP338
A	TOY604
A	FE2607
A	HOH821
A	HOH833
A	HOH860

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TOY A 604

Chain	Residue
A	ASP12
A	HIS14
A	PHE169
A	GLU172
A	GLU176
A	ASP228
A	TYR230
A	ADP603
A	HOH821
A	HOH834
A	HOH861
A	HOH921

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 605

Chain	Residue
A	SER530
A	ADP601
A	CP602
A	HOH987
A	HOH988

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 606

Chain	Residue
A	LEU322
A	ARG324
A	VAL327

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 607

Chain	Residue
A	HIS114
A	HIS118
A	ASP137
A	ASP338
A	ADP603

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 608

Chain	Residue
A	GLU369
A	PHE370
A	ALA409
A	GLY411
A	ARG423
A	GLY560
A	HOH854

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	353
Details	Region: {"description":"Kae1-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22383337","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22383337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VET","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22383337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22383337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VEX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---