3V9T

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

3V9T の概要

• エントリーDOI: 10.2210/pdb3v9t/pdb
• 関連するPDBエントリー: 3B1M 3LMP 3V9V 3V9Y
• 分子名称: Peroxisome proliferator-activated receptor gamma, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (9aS)-8-acetyl-N-[(3-ethoxynaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: three-layered alpha-helical sandwich, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231 Q9UBK2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35009.49

構造登録者

Matsui, Y.,Hanzawa, H. (登録日: 2011-12-28, 公開日: 2012-02-01, 最終更新日: 2023-11-08)

• 主引用文献: Furukawa, A.,Arita, T.,Fukuzaki, T.,Satoh, S.,Mori, M.,Honda, T.,Matsui, Y.,Wakabayashi, K.,Hayashi, S.,Araki, K.,Ohsumi, J.; Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR(gamma) partial agonists; Bioorg.Med.Chem.Lett., 22:1348-1351, 2012; PubMed: 22225641; DOI: 10.1016/j.bmcl.2011.12.066

実験手法

X-RAY DIFFRACTION (1.65 Å)