3V8S

Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18)

3V8S の概要

• エントリーDOI: 10.2210/pdb3v8s/pdb
• 分子名称: Rho-associated protein kinase 1, 1-(1H-indazol-5-yl)-3-(2-phenylethyl)urea (3 entities in total)
• 機能のキーワード: kinase, dimerization, myosin, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13464
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 191063.94

構造登録者

Martin, M.P.,Zhu, J.-Yi.,Schonbrunn, E. (登録日: 2011-12-23, 公開日: 2012-02-08, 最終更新日: 2023-09-13)

• 主引用文献: Li, R.,Martin, M.P.,Liu, Y.,Wang, B.,Patel, R.A.,Zhu, J.Y.,Sun, N.,Pireddu, R.,Lawrence, N.J.,Li, J.,Haura, E.B.,Sung, S.S.,Guida, W.C.,Schonbrunn, E.,Sebti, S.M.; Fragment-based and structure-guided discovery and optimization of rho kinase inhibitors.; J.Med.Chem., 55:2474-2478, 2012; PubMed: 22272748; DOI: 10.1021/jm201289r

実験手法

X-RAY DIFFRACTION (2.286 Å)