3V8G

Crystal structure of an asymmetric trimer of a glutamate transporter homologue (GltPh)

Summary for 3V8G

Entry DOI	10.2210/pdb3v8g/pdb
Related	1XFH 2NWL 2NWW 2NWX 3KBC 3V8F
Descriptor	sodium-coupled L-aspartate transporter, ASPARTIC ACID, SODIUM ION (3 entities in total)
Functional Keywords	sodium ions, l-arpartate, membrane, transport protein
Biological source	Pyrococcus horikoshii
Total number of polymer chains	6
Total formula weight	268950.24
Authors	Verdon, G.,Boudker, O. (deposition date: 2011-12-22, release date: 2012-02-15, Last modification date: 2024-02-28)
Primary citation	Verdon, G.,Boudker, O. Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nat.Struct.Mol.Biol., 19:355-357, 2012 Cited by PubMed Abstract: We report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes. PubMed: 22343718 DOI: 10.1038/nsmb.2233 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.66 Å)

Structure validation