3V7T

Crystal Structure of Human Beta-Tryptase Complexed with a Synthetic Inhibitor with a Tropanylamide Scaffold

3V7T の概要

• エントリーDOI: 10.2210/pdb3v7t/pdb
• 分子名称: TPSB2 protein, {(3-exo)-3-[5-(aminomethyl)-2-fluorophenyl]-8-azabicyclo[3.2.1]oct-8-yl}(4-bromo-3-methyl-5-propoxythiophen-2-yl)methanone, CARBONATE ION, ... (4 entities in total)
• 機能のキーワード: tryptase, serine protease, tetramer, protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 112067.51

構造登録者

Zhang, Y.,Colonna, C.,Michot, N. (登録日: 2011-12-22, 公開日: 2012-03-14, 最終更新日: 2017-11-08)

• 主引用文献: Liang, G.,Choi-Sledeski, Y.M.,Shum, P.,Chen, X.,Poli, G.B.,Kumar, V.,Minnich, A.,Wang, Q.,Tsay, J.,Sides, K.,Kang, J.,Zhang, Y.; A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity; Bioorg.Med.Chem.Lett., 22:1606-1610, 2012; PubMed: 22264487; DOI: 10.1016/j.bmcl.2011.12.127

実験手法

X-RAY DIFFRACTION (2.09 Å)