3V7S

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 0364

Summary for 3V7S

Entry DOI	10.2210/pdb3v7s/pdb
Related	1HXD 2CGH 2EAY 2EWN 3V7C 3V7R 3V8J 3V8K 3V8L
Descriptor	Biotin ligase, 5-methyl-3-[4-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one (3 entities in total)
Functional Keywords	biotin protein ligase, biotin, metabolism, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	38499.45
Authors	Yap, M.Y.,Pendini, N.R. (deposition date: 2011-12-21, release date: 2012-04-25, Last modification date: 2024-03-20)
Primary citation	Soares da Costa, T.P.,Tieu, W.,Yap, M.Y.,Pendini, N.R.,Polyak, S.W.,Sejer Pedersen, D.,Morona, R.,Turnidge, J.D.,Wallace, J.C.,Wilce, M.C.,Booker, G.W.,Abell, A.D. Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287:17823-17832, 2012 Cited by PubMed: 22437830 DOI: 10.1074/jbc.M112.356576 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation