3V4A

Structure of ar lbd with activator peptide and sarm inhibitor 2

Summary for 3V4A

• Entry DOI: 10.2210/pdb3v4a/pdb
• Related: 2AMA 2Z4J 3V49
• Descriptor: Androgen receptor, (5R)-3-(3,4-dichlorophenyl)-5-(4-hydroxyphenyl)-1,5-dimethyl-2-thioxoimidazolidin-4-one, SULFATE ION, ... (5 entities in total)
• Functional Keywords: diarylhydantoin, synthesis, antiandrogen, androgen receptor, testosterone, selective androgen receptor modulator, dihydrotestosterone, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P10275 P10275
• Total number of polymer chains: 2
• Total formula weight: 30790.83

Authors

Nique, F.,Hebbe, S.,Peixoto, C.,Annoot, D.,Lefrancois, J.-M.,Duval, E.,Michoux, L.,Triballeau, N.,Lemoullec, J.M.,Mollat, P.,Thauvin, M.,Prange, T.,Minet, D.,Clement-Lacroix, P.,Robin-Jagerschmidt, C.,Fleury, D.,Guedin, D.,Deprez, P. (deposition date: 2011-12-14, release date: 2012-09-05, Last modification date: 2023-09-13)

• Primary citation: Nique, F.,Hebbe, S.,Peixoto, C.,Annoot, D.,Lefrancois, J.-M.,Duval, E.,Michoux, L.,Triballeau, N.,Lemoullec, J.M.,Mollat, P.,Thauvin, M.,Prange, T.,Minet, D.,Clement-Lacroix, P.,Robin-Jagerschmidt, C.,Fleury, D.,Guedin, D.,Deprez, P.; Discovery of diarylhydantoins as new selective androgen receptor modulators.; J.Med.Chem., 55:8225-8235, 2012; PubMed: 22897611; DOI: 10.1021/jm300249m

Experimental method

X-RAY DIFFRACTION (1.95 Å)