3V49

Structure of ar lbd with activator peptide and sarm inhibitor 1

Summary for 3V49

Entry DOI	10.2210/pdb3v49/pdb
Related	2AMA 2Z4J 3V4A
Descriptor	Androgen receptor, Androgen receptor, activator peptide, 4-[(4R)-4-(4-hydroxyphenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile, ... (5 entities in total)
Functional Keywords	diarylhydantoin, synthesis, sarm, antiandrogen, ligand binding domain, testosterone, dihydrotestosterone, transcription, sarm (selective androgen receptor modulator)
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : P10275 P10275
Total number of polymer chains	2
Total formula weight	32748.99
Authors	Nique, F.,Hebbe, S.,Peixoto, C.,Annoot, D.,Lefrancois, J.-M.,Duval, E.,Michoux, L.,Triballeau, N.,Lemoullec, J.-M.,Mollat, P.,Thauvin, M.,Prange, T.,Minet, D.,Clement-Lacroix, P.,Robin-Jagerschmidt, C.,Fleury, D.,Guedin, D.,Deprez, P. (deposition date: 2011-12-14, release date: 2012-09-05, Last modification date: 2023-09-13)
Primary citation	Nique, F.,Hebbe, S.,Peixoto, C.,Annoot, D.,Lefrancois, J.-M.,Duval, E.,Michoux, L.,Triballeau, N.,Lemoullec, J.M.,Mollat, P.,Thauvin, M.,Prange, T.,Minet, D.,Clement-Lacroix, P.,Robin-Jagerschmidt, C.,Fleury, D.,Guedin, D.,Deprez, P. Discovery of diarylhydantoins as new selective androgen receptor modulators. J.Med.Chem., 55:8225-8235, 2012 Cited by PubMed: 22897611 DOI: 10.1021/jm300249m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation