3V49

Structure of ar lbd with activator peptide and sarm inhibitor 1

3V49 の概要

• エントリーDOI: 10.2210/pdb3v49/pdb
• 関連するPDBエントリー: 2AMA 2Z4J 3V4A
• 分子名称: Androgen receptor, Androgen receptor, activator peptide, 4-[(4R)-4-(4-hydroxyphenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile, ... (5 entities in total)
• 機能のキーワード: diarylhydantoin, synthesis, sarm, antiandrogen, ligand binding domain, testosterone, dihydrotestosterone, transcription, sarm (selective androgen receptor modulator)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : P10275 P10275
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32748.99

構造登録者

Nique, F.,Hebbe, S.,Peixoto, C.,Annoot, D.,Lefrancois, J.-M.,Duval, E.,Michoux, L.,Triballeau, N.,Lemoullec, J.-M.,Mollat, P.,Thauvin, M.,Prange, T.,Minet, D.,Clement-Lacroix, P.,Robin-Jagerschmidt, C.,Fleury, D.,Guedin, D.,Deprez, P. (登録日: 2011-12-14, 公開日: 2012-09-05, 最終更新日: 2023-09-13)

• 主引用文献: Nique, F.,Hebbe, S.,Peixoto, C.,Annoot, D.,Lefrancois, J.-M.,Duval, E.,Michoux, L.,Triballeau, N.,Lemoullec, J.M.,Mollat, P.,Thauvin, M.,Prange, T.,Minet, D.,Clement-Lacroix, P.,Robin-Jagerschmidt, C.,Fleury, D.,Guedin, D.,Deprez, P.; Discovery of diarylhydantoins as new selective androgen receptor modulators.; J.Med.Chem., 55:8225-8235, 2012; PubMed: 22897611; DOI: 10.1021/jm300249m

実験手法

X-RAY DIFFRACTION (1.7 Å)