3V19

Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health

Summary for 3V19

• Entry DOI: 10.2210/pdb3v19/pdb
• Related: 3V1G
• Descriptor: Insulin, ZINC ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: zinc-binding site, long-acting insulin analog, receptor binding, protein engineering, insulin fibrillation, hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 4
• Total formula weight: 12033.28

Authors

Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A. (deposition date: 2011-12-09, release date: 2012-12-12, Last modification date: 2023-09-13)

• Primary citation: Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A.; Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)