3V19

Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health

3V19 の概要

• エントリーDOI: 10.2210/pdb3v19/pdb
• 関連するPDBエントリー: 3V1G
• 分子名称: Insulin, ZINC ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: zinc-binding site, long-acting insulin analog, receptor binding, protein engineering, insulin fibrillation, hormone
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01308 P01308
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 12033.28

構造登録者

Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A. (登録日: 2011-12-09, 公開日: 2012-12-12, 最終更新日: 2023-09-13)

• 主引用文献: Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A.; Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)