3V19

Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health

3V19 の概要

関連するPDBエントリー3V1G
分子名称Insulin, ZINC ION, CHLORIDE ION, ... (6 entities in total)
機能のキーワードzinc-binding site, long-acting insulin analog, receptor binding, protein engineering, insulin fibrillation, hormone
由来する生物種Homo sapiens (human)
細胞内の位置Secreted P01308 P01308
ポリマー鎖数4
分子量合計12033.28
構造登録者
主引用文献
Wan, Z.L.,Hua, Q.X.,Wickramasinghe, N.P.,Huang, K.,Petkova, A.T.,Hu, S.Q.,Phillips, N.B.,Yeh, I.J.,Whittake, J.,Ismail-Beigi, F.,Katsoyyannis, P.G.,Tycko, R.,Weiss, M.A.
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published,
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266152.1%6.5%13.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード