3V0W
Crystal structure of Fab WN1 222-5 in complex with LPS
Summary for 3V0W
Entry DOI | 10.2210/pdb3v0w/pdb |
Descriptor | WN1 222-5 Fab (IgG2a) light chain, WN1 222-5 Fab (IgG2a) heavy chain, 2-amino-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-[L-glycero-alpha-D-manno-heptopyranose-(1-7)]4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-3)-4-O-phosphono-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, ... (5 entities in total) |
Functional Keywords | beta barrel, antibody, fab, immune system |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 49644.15 |
Authors | Gomery, K.,Evans, S.V. (deposition date: 2011-12-08, release date: 2012-12-05, Last modification date: 2020-07-29) |
Primary citation | Gomery, K.,Muller-Loennies, S.,Brooks, C.L.,Brade, L.,Kosma, P.,Di Padova, F.,Brade, H.,Evans, S.V. Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS. Proc.Natl.Acad.Sci.USA, 109:20877-20882, 2012 Cited by PubMed: 23184990DOI: 10.1073/pnas.1209253109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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