3UXW
Crystal Structures of an A-T-hook/DNA complex
Summary for 3UXW
| Entry DOI | 10.2210/pdb3uxw/pdb |
| Descriptor | dodecamer DNA, A-T hook peptide (3 entities in total) |
| Functional Keywords | a-t hook-dna complex, oligonucletide duplex hmga-1a protein, dna-peptide complex, dna/peptide |
| Total number of polymer chains | 12 |
| Total formula weight | 33797.03 |
| Authors | Fonfria-Subiros, E.,Acosta-Reyes, F.J.,Saperas, N.,Pous, J.,Subirana, J.A.,Campos, J.L. (deposition date: 2011-12-05, release date: 2012-05-23, Last modification date: 2024-11-06) |
| Primary citation | Fonfria-Subiros, E.,Acosta-Reyes, F.,Saperas, N.,Pous, J.,Subirana, J.A.,Campos, J.L. Crystal structure of a complex of DNA with one AT-hook of HMGA1. Plos One, 7:e37120-e37120, 2012 Cited by PubMed Abstract: We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)(2), which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT-hook forms hydrogen bonds between main-chain NH groups and thymines in the minor groove, DNA is bent and the minor groove is widened. PubMed: 22615915DOI: 10.1371/journal.pone.0037120 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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