3UXH

Design, Synthesis and Biological Evaluation of Potetent Quinoline and Pyrroloquinoline Ammosamide Analogues as Inhibitors of Quinone Reductase 2

3UXH の概要

• エントリーDOI: 10.2210/pdb3uxh/pdb
• 関連するPDBエントリー: 3UXE
• 分子名称: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: quinone reductase, cytosol, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P16083
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53983.98

構造登録者

Cushman, M.,Mesecar, A.D.,Fanwick, P.E.,Narasimha, R.,Jensen, K.C. (登録日: 2011-12-05, 公開日: 2012-01-18, 最終更新日: 2024-05-22)

• 主引用文献: Reddy, P.V.,Jensen, K.C.,Mesecar, A.D.,Fanwick, P.E.,Cushman, M.; Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2.; J.Med.Chem., 55:367-377, 2012; PubMed: 22206487; DOI: 10.1021/jm201251c

実験手法

X-RAY DIFFRACTION (1.53 Å)