3UW9

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K8acK12ac)

3UW9 の概要

• エントリーDOI: 10.2210/pdb3uw9/pdb
• 分子名称: Bromodomain-containing protein 4, histone 4 peptide (H4K8acK12ac) (3 entities in total)
• 機能のキーワード: bromodomain, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, peptide complex, structural genomics consortium, sgc, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (By similarity): O60885; Nucleus: P62805
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 62626.12

構造登録者

Filippakopoulos, P.,Felletar, I.,Picaud, S.,Keates, T.,Muniz, J.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2011-12-01, 公開日: 2012-03-14, 最終更新日: 2024-04-03)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.; Histone recognition and large-scale structural analysis of the human bromodomain family.; Cell(Cambridge,Mass.), 149:214-231, 2012; PubMed: 22464331; DOI: 10.1016/j.cell.2012.02.013

実験手法

X-RAY DIFFRACTION (2.3 Å)