3UW5
Crystal structure of the BIR domain of MLIAP bound to GDC0152
Summary for 3UW5
Entry DOI | 10.2210/pdb3uw5/pdb |
Related PRD ID | PRD_001020 |
Descriptor | Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 4, GDC-0152, ZINC ION, ... (5 entities in total) |
Functional Keywords | apoptosis inhibitor, bir domain |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 4 |
Total formula weight | 27465.27 |
Authors | Maurer, B.,Hymowitz, S.G. (deposition date: 2011-11-30, release date: 2012-02-22, Last modification date: 2017-08-02) |
Primary citation | Flygare, J.A.,Beresini, M.,Budha, N.,Chan, H.,Chan, I.T.,Cheeti, S.,Cohen, F.,Deshayes, K.,Doerner, K.,Eckhardt, S.G.,Elliott, L.O.,Feng, B.,Franklin, M.C.,Reisner, S.F.,Gazzard, L.,Halladay, J.,Hymowitz, S.G.,La, H.,Lorusso, P.,Maurer, B.,Murray, L.,Plise, E.,Quan, C.,Stephan, J.P.,Young, S.G.,Tom, J.,Tsui, V.,Um, J.,Varfolomeev, E.,Vucic, D.,Wagner, A.J.,Wallweber, H.J.,Wang, L.,Ware, J.,Wen, Z.,Wong, H.,Wong, J.M.,Wong, M.,Wong, S.,Yu, R.,Zobel, K.,Fairbrother, W.J. Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). J.Med.Chem., 55:4101-4113, 2012 Cited by PubMed: 22413863DOI: 10.1021/jm300060k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
Download full validation report