3UW5

Crystal structure of the BIR domain of MLIAP bound to GDC0152

3UW5 の概要

• エントリーDOI: 10.2210/pdb3uw5/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001020
• 分子名称: Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 4, GDC-0152, ZINC ION, ... (5 entities in total)
• 機能のキーワード: apoptosis inhibitor, bir domain
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P98170
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 27465.27

構造登録者

Maurer, B.,Hymowitz, S.G. (登録日: 2011-11-30, 公開日: 2012-02-22, 最終更新日: 2017-08-02)

• 主引用文献: Flygare, J.A.,Beresini, M.,Budha, N.,Chan, H.,Chan, I.T.,Cheeti, S.,Cohen, F.,Deshayes, K.,Doerner, K.,Eckhardt, S.G.,Elliott, L.O.,Feng, B.,Franklin, M.C.,Reisner, S.F.,Gazzard, L.,Halladay, J.,Hymowitz, S.G.,La, H.,Lorusso, P.,Maurer, B.,Murray, L.,Plise, E.,Quan, C.,Stephan, J.P.,Young, S.G.,Tom, J.,Tsui, V.,Um, J.,Varfolomeev, E.,Vucic, D.,Wagner, A.J.,Wallweber, H.J.,Wang, L.,Ware, J.,Wen, Z.,Wong, H.,Wong, J.M.,Wong, M.,Wong, S.,Yu, R.,Zobel, K.,Fairbrother, W.J.; Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).; J.Med.Chem., 55:4101-4113, 2012; PubMed: 22413863; DOI: 10.1021/jm300060k

実験手法

X-RAY DIFFRACTION (1.71 Å)