3URN

Crystal Structure of PTE mutant H254G/H257W/L303T/K185R/I274N/A80V/S61T with cyclohexyl methylphosphonate inhibitor

Summary for 3URN

• Entry DOI: 10.2210/pdb3urn/pdb
• Related: 3UPM 3UR2 3UR3 3URA 3URB 3URQ
• Descriptor: Parathion hydrolase, COBALT (II) ION, cyclohexyl methylphosphonate, ... (5 entities in total)
• Functional Keywords: metalloenzyme, tim barrel, nerve agents, phosphotriesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Brevundimonas diminuta
• Cellular location: Cell membrane; Peripheral membrane protein: P0A434
• Total number of polymer chains: 2
• Total formula weight: 71914.11

Authors

Tsai, P.,Fox, N.G.,Li, Y.,Barondeau, D.P.,Raushel, F.M. (deposition date: 2011-11-22, release date: 2012-08-01, Last modification date: 2023-12-06)

• Primary citation: Tsai, P.C.,Fox, N.,Bigley, A.N.,Harvey, S.P.,Barondeau, D.P.,Raushel, F.M.; Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.; Biochemistry, 51:6463-6475, 2012; PubMed: 22809162; DOI: 10.1021/bi300811t

Experimental method

X-RAY DIFFRACTION (1.95 Å)