Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3UQW

Crystal structure of BACE1 with its inhibitor

Summary for 3UQW
Entry DOI10.2210/pdb3uqw/pdb
Related3UQP 3UQR 3UQU 3UQX 4DV9 4DVF
DescriptorBeta-secretase 1, ethyl 1-{(2S,3S)-3-[(3-{[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl}-5-[methyl(methylsulfonyl)amino]benzoyl)amino]-2-hydroxy-4-phenylbutyl}-1H-pyrazole-4-carboxylate, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase, beta-secretase, bace1, memapsin 2, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight49094.81
Authors
Chen, T.T.,Chen, W.Y.,Xu, Y.C. (deposition date: 2011-11-21, release date: 2012-11-21, Last modification date: 2024-10-30)
Primary citationXu, Y.C.,Chen, W.Y.,Chen, T.T.
Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations
to be published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon