3UPR
HLA-B*57:01 complexed to pep-V and Abacavir
Summary for 3UPR
Entry DOI | 10.2210/pdb3upr/pdb |
Related | 2BVO 2BVP 2HJL 2RFX |
Descriptor | HLA class I histocompatibility antigen, B-57 alpha chain, pep-V, Beta-2-microglobulin, ... (6 entities in total) |
Functional Keywords | hla-b*57:01, mhc, antigen presenting cell, t-cell receptor, human leukocyte antigen, drug hypersensitivity, abacavir hypersensitivity, repertoire-altering small molecule, immune response, immunoglobulin-like beta-sandwich, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P18465 Secreted: P61769 |
Total number of polymer chains | 6 |
Total formula weight | 89961.09 |
Authors | Pompeu, Y.A.,Ostrov, D.A. (deposition date: 2011-11-18, release date: 2012-06-13, Last modification date: 2023-09-13) |
Primary citation | Ostrov, D.A.,Grant, B.J.,Pompeu, Y.A.,Sidney, J.,Harndahl, M.,Southwood, S.,Oseroff, C.,Lu, S.,Jakoncic, J.,de Oliveira, C.A.,Yang, L.,Mei, H.,Shi, L.,Shabanowitz, J.,English, A.M.,Wriston, A.,Lucas, A.,Phillips, E.,Mallal, S.,Grey, H.M.,Sette, A.,Hunt, D.F.,Buus, S.,Peters, B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc.Natl.Acad.Sci.USA, 109:9959-9964, 2012 Cited by PubMed: 22645359DOI: 10.1073/pnas.1207934109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.999 Å) |
Structure validation
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